Chronic medical conditions are another important possibility. Heart disease, kidney disease, liver disorders, chronic venous insufficiency, and problems with the lymphatic system can all cause fluid to accumulate in the legs. Because these conditions affect how the body circulates blood or removes excess fluid, swelling may become more noticeable at the end of the day or after prolonged standing.
Certain medications can also contribute to swollen ankles and feet. Blood pressure medications, steroids, anti-inflammatory drugs, hormone therapy, and some diabetes medications may cause fluid retention as a side effect. If swelling begins soon after starting a new medication, consult your healthcare provider before making any changes.
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